Blog - Publication
08/10/2025
Advanced Side-Chain Protection with THP and Trt
Replace tBu with THP or Trt and give your amino acids a smarter protection, removable under milder acidic conditions to minimize side products. Learn more in our latest publication!
02/07/2025
Sarcosine Oligomers as Building Blocks for SPPS
Optimize your drug delivery with non-immunogenic biodegradable PEG alternatives and discover strategies for synthesizing defined sarcosine oligomers for targeted drug conjugation.
17/04/2025
Investigating the synthesis of dodeca oligomers of Sarcosine using Fmoc-Sar-OH, Fmoc-(Sar)2-OH and Fmoc-(Sar)4-OH
Polysarcosines are flexible and enzyme-resistant polymers, made from the biocompatible non-proteinogenic amino acid sarcosine. Unlike PEGs, they are not reported to trigger immune responses.
10/03/2025
Solid-Phase Synthesis of Peptide Hydrazides: Moving Toward Green Chemistry
Discover a greener synthetic approach towards peptide hydrazides - valuable precursors, e.g., for the synthesis of peptide thioesters, widely applied building blocks for native chemical ligation.
11/09/2024
Interview with C&EN
Our CSO and VP Business Development Dr. Thomas Bruckdorfer had the pleasure to talk to C&EN about our linkerology platform.
17/07/2024
Novel amino-Li resin for water-based solid-phase peptide synthesis
Amino-Li resin – a cross-linked polyacrylic amide solid support suitable for the synthesis of peptides and biomolecules, which is compatible with organic as well as aqueous solvents.
19/12/2022
![Incorporation of pseudoproline monomer (Fmoc-Thr[ψMe,Mepro]–OH) facilitates efficient solid-phase synthesis of difficult peptides](https://cdn.iris-biotech.de/media/nextgenimages/media/blog/Publikation_Dez2022.webp)
Incorporation of pseudoproline monomer (Fmoc-Thr[ψMe,Mepro]–OH) facilitates efficient solid-phase synthesis of difficult peptides
Herein we investigate the incorporation of the Fmoc-Thr-pseudoproline monomer during Fmoc SPPS. Typically, pseudoprolines are incorporated as preformed dipeptides. However, the possibility of using the monomer adds flexibility to the synthesis.
05/09/2022
Solid-Phase Peptide Synthesis Using a Four-Dimensional (Safety-Catch) Protecting Group Scheme
As the molecular diversity of cyclic and branched peptides becomes more and more challenging, a high level of orthogonal dimensionality is required. Herein, we present a new category of orthogonal protecting groups.
05/09/2022
Solid-Phase Synthesis of an “Inaccessible” hGH-Derived Peptide Using a Pseudoproline Monomer and SIT-Protection for Cysteine
Herein, we report the first-time SPPS of a special peptide sequence via employment of of a serine pseudoproline building block as well as sec-isamyl mercaptan (SIT) as cysteine protecting group.
27/12/2021
2-Chlorotrityl Chloride and 4-Methylbenzhydryl Bromide Resin Loading Using the Mixture of Organic Solvents: A “Greener” Alternative to Dichloromethane and N,N-Dimethylformamide
Common protocols for the loading of 2-CTC and MBH-Br resins presume the application of DCM, THF, or DMF; these solvents are considered as undesirable in accordance with modern regulatory rules.