Blog - Linkerology
03/12/2025
Escaping Aggregation: Traceless Linkers for Hydrophobic Peptides
Struggling with aggregating peptides or poor solubility? Take the rescue route: introduce solubility tags with our removable linkers. Learn more about your linker choices in our blog.
05/11/2025
CliCr®: Practical Guidelines and Decision Flowchart
Achieve reproducible conjugation with CliCr® reagents under well-defined conditions. Follow our CliCr® flowchart to guide your decision-making process and select the optimal setup for your reaction.
24/09/2025
The Safety-Catch Noki-Linker
The Noki-Linker is designed to make peptide synthesis more sustainable while delivering cleaner products. With a build-in safety-catch, it reduces TFA usage. Curious how? Read on!
10/09/2025
PotM: Next Generation Maleimides
Next generation bromo maleimides address the well-known limitations of conventional maleimides. Explore our available building blocks, their advantages, and how to use them!
16/07/2025
PotM: Novel Bifunctional Linkers for Sequential Click Conjugations
Ynamines are uniquely reactive alkynes with which azides react preferentially, even in the presence of other alkynes. Learn how to take advantage of their selectivity.
02/07/2025
Sarcosine Oligomers as Building Blocks for SPPS
Optimize your drug delivery with non-immunogenic biodegradable PEG alternatives and discover strategies for synthesizing defined sarcosine oligomers for targeted drug conjugation.
18/06/2025
Sieber Resins for the Synthesis of C-Terminal Amides
C-Terminal amides are key to peptide drug design. They are stable, lipophilic, and naturally occurring. Learn how the Sieber resin supports their synthesis with gentle, efficient cleavage protocols.
09/04/2025
PotM: Protein Kinase Inhibitors with a Linkable Handle
Unlock new frontiers of kinase inhibitors - derivatives with aminoalkyl handles allow for precision targeting and pave the way for novel drug delivery strategies and smarter kinase therapeutics.
26/02/2025
PotM: Trifunctionality - A Photocaged Maleimide with Carboxy Function
Just a flash away! Employ our novel nitroveratryl-maleimido-beta-alanine linker derivate and generate stable thioether conjugates upon spatiotemporally controllable irradiation with UV light!
15/10/2024
HMPO: A pH-Responsive Linker for Targeted Drug Delivery
HMPO (5-(hydroxymethyl)pyrogallol orthoester), a plasma-stable, pH-sensitive, 1,6-self-immolative crosslinker derived from the natural product gallic acid. Discover its properties!