Blog - Click Chemistry
25/03/2026
Proximity-Induced SuFEx Click Chemistry
Fluorosulfate-tyrosine (OSF-Tyr) brings reactive docking sites into proteins and peptides. Discover this “click-type” and learn how proximity-activated SuFEx chemistry enables covalent modification.
11/03/2026
PotM: Click faster than you can Click!
Picolyl azide-based linkers allow for ultra-fast CuAAC in the presence of extremely low copper concentrations – even in cellular environments that don’t tolerate usual click conditions.
05/11/2025
CliCr®: Practical Guidelines and Decision Flowchart
Achieve reproducible conjugation with CliCr® reagents under well-defined conditions. Follow our CliCr® flowchart to guide your decision-making process and select the optimal setup for your reaction.
16/07/2025
PotM: Novel Bifunctional Linkers for Sequential Click Conjugations
Ynamines are uniquely reactive alkynes with which azides react preferentially, even in the presence of other alkynes. Learn how to take advantage of their selectivity.
15/01/2025
Frequently Asked CliCr® Questions
Improve your click chemistry synthesis with CliCr® - the 7-membered ring strained alkyne TMTHSI is the smallest, most hydrophilic, and highly reactive reagent for copper-free click chemistry.
29/05/2024
Norbornenes – Will You Click Me?
Proposing norbornenes – strained, bicyclic alkenes for fast, copper-free, biocompatible click-conjugation with tetrazines. Read on for more details on applications and available products!
15/11/2023
Automated Peptide Synthesis
The discovery of the Merrifield peptide synthesis paved the way for automated solid-phase peptide synthesis (SPPS) enabling fast and convenient simultaneous peptide synthesis.
20/09/2023
PotM: Multiconjugates via Simultaneous Double-Click Reaction
Discover our new building block 4-(azido-propyl-tetrazine)phenylalanine (pTAF) and make use of the orthogonality of the 2nd and 3rd generation Click reaction to build multiconjugates via double-Click.
22/08/2023
Cell-Free Bioengineering & Linkerology®
Bioengineering in combination with Linkerology®. Check out the unique options for membrane proteins, recombinant immunotoxins (RITs) and novel antibody-drug conjugates.
16/05/2023
CliCr® - a Reactive and Soluble Bioorthogonal Click Reagent
Building blocks with a strained triple bond do not require copper catalysis when used in click chemistry. Discover CliCr®: improved solubility in aqueous conditions and high reactivity! Click here!