Blog - Building Blocks
25/03/2026
The Endless Variability of Piperidine-Based Amino Acids
Pipecolic, nipecotic, and homonipecotic acid are the basic motifs that combine piperidine with carboxylic acids. And they are only the starting points for countless MedChem building blocks.
11/03/2026
PotM: Click faster than you can Click!
Picolyl azide-based linkers allow for ultra-fast CuAAC in the presence of extremely low copper concentrations – even in cellular environments that don’t tolerate usual click conditions.
25/02/2026
Hydrazide as Asp Side-Chain Protecting Group
Keep your peptide synthesis clean – prevent aspartimide formation by using our novel aspartic acid hydrazide building block Fmoc-L-Asp(NH-NMe-Boc)-OH. Read our blog for more information!
11/02/2026
Masking the Peptide Backbone in SPPS
Backbone protecting groups provide peptides with temporary disguise: they mask backbone amides to control reactivity and suppress aggregation until synthesis is complete. Learn more!
11/02/2026
PotM: Staple and Watch your Peptide in One
Diyne-girder bridged stapled peptides in the ideal helical geometry are accessible through our new alkyne functionalized building block. They can be watched by Raman microscopy.
28/01/2026
An SPPS-Ready Entry to Bioluminescent Peptides
Make your peptides glow by treating luciferin like an amino acid! Fmoc protection makes peptide-luciferin conjugates easy to assemble by Fmoc-SPPS. Curious how it works? Read on.
28/01/2026
PotM: A Tripeptide Pseudoproline Building Block
Pseudoprolines act as molecular hinges: introducing precise turns that disrupt early folding and reduce aggregation in challenging peptide sequences. Read on to learn how they work!
03/12/2025
PotM: Small Dyes, Bright Colors
Solvatochromic dyes of our building blocks provide a fluorescent color palette that enables the integration of sensitive optical sensors into peptides, proteins, and other organic systems.
22/10/2025
Locked Nucleic Acid (LNA) Phosphoramidites
LNA Building blocks improve duplex stability and binding specificity of oligos by locking the sugar backbone into a rigid 3'-endo envelope conformation. Explore their unique advantages!
24/09/2025
Products for Green Peptide Chemistry
Recent years have seen major advances in greener peptide synthesis. To highlight such products, we introduced the category "Green Chemistry" on our website.